반응 #60032

반응 방정식

tert-butyl 6-chloropyridine-3-carboxylate

ethylenediamine

→

tert-butyl 6-[(2-aminoethyl)amino]pyridine-3-carboxylate

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   기타The residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution
3. 3
   추출The aqueous layer was extracted a further three times with dichloromethane
4. 4
   세척The combined organic layers were washed with water
5. 5
   기타dried
6. 6
   농축concentrated in vacuo

실험 절차

The tert-butyl 6-chloropyridine-3-carboxylate was heated with ethylenediamine (20 ml) at 80° C. overnight. The solvent was removed in vacuo. The residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution. The aqueous layer was extracted a further three times with dichloromethane. The combined organic layers were washed with water, dried and concentrated in vacuo to give tert-butyl 6-[(2-aminoethyl)amino]pyridine-3-carboxylate.

출처