반응 #60024

반응 방정식

Ethyl 6-chloronicotinate

morpholine

Acetonitrile

→

ethyl 6-morpholin-4-ylpyridine-3-carboxylate

용매

water

반응 조건

후처리

1. 1
   workup.WAITIn less than 5 minutes at this temperature
2. 2
   기타a thick paste formed
3. 3
   온도heating
4. 4
   온도The mixture was cooled
5. 5
   추출extracted with ethyl acetate
6. 6
   기타The organic layer was dried
7. 7
   농축concentrated in vacuo

실험 절차

Ethyl 6-chloronicotinate (5.0 g) and morpholine (10 ml) were mixed and then heated to 100° C. In less than 5 minutes at this temperature, a thick paste formed. Acetonitrile (15 ml) was added and heating was continued overnight at 90° C. The mixture was cooled, diluted with water and extracted with ethyl acetate. The organic layer was dried and concentrated in vacuo to give ethyl 6-morpholin-4-ylpyridine-3-carboxylate as a white solid.

출처