반응 #60014

반응 방정식

4-Octylaniline

18-crown-6

K2CO3

1-chloro-4-iodobenzene

→

bis(4-chlorophenyl)(4-octylphenyl)amine

용매

1,2-dichlorobenzene

dichloromethane

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux for 24 hours under argon
3. 3
   여과filtered
4. 4
   기타After removal of solvent
5. 5
   workup.DISTILLATIONby distillation
6. 6
   기타the product was purified

실험 절차

4-Octylaniline (5.00 g, 244.4 mmol), 18-crown-6 (1.29 g, 4.9 mmol), K2CO3 (27.64 g, 194.8 mmol), 1-chloro-4-iodobenzene (14.51 g, 60.9 mmol, copper (6.19 g, 97.4 mmol), and 1,2-dichlorobenzene (100 mL) were added in a 250 mL flask with a condenser connected to a Dean Stark apparatus. The mixture was heated to reflux for 24 hours under argon. The reaction mixture was then cooled to room temperature, diluted with dichloromethane, and filtered. After removal of solvent by distillation, the product was purified using silica gel column chromatography using hexane as eluant. The yield was 4.18 g (40.3%).

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