반응 #6001

반응 방정식

isobutyryl chloride

N-carbobenzoxydopamine

pyridine

sodium carbonate

→

desired compound

수율 74.7%

3,4-di-O-isobutyryl -N-carbobenzoxydopamine

수율 74.7%

반응 조건

후처리

1. 1
   기타to react at 35° to 40° C. for 3 hours
2. 2
   workup.ADDITIONThen, the reaction mixture was poured into ice
3. 3
   추출The mixture was extracted with diethyl ether
4. 4
   추출the resulting extract
5. 5
   건조was dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled
7. 7
   기타the thus-obtained crude crystals
8. 8
   기타were recrystallized from diisopropyl ether/petroleum ether (1:2 by volume)

실험 절차

To 80 ml of a pyridine solution containing 10.7 g (37 mmol) of N-carbobenzoxydopamine obtained in Synthetic Example 1-(1) was added dropwise 9.9 g (93 mmol) of isobutyryl chloride at 5° to 10° C. After stirring at room temperature for 12 hours, the mixture was allowed to react at 35° to 40° C. for 3 hours. Then, the reaction mixture was poured into ice and a sodium carbonate solution and stirred at room temperature for 30 minutes. The mixture was extracted with diethyl ether and the resulting extract was dried over anhydrous magnesium sulfate. The solvent was distilled and the thus-obtained crude crystals were recrystallized from diisopropyl ether/petroleum ether (1:2 by volume) to obtain 11.9 g (yield: 74.7%) of the desired compound in the form of white cyrstals (m.p. 44°-46° C.).

출처