반응 #5999

반응 방정식

benzyloxycarbonyl chloride

hydrochloric acid

sodium borate

dopamine hydrochloride

sodium hydroxide

sodium hydroxide

→

desired compound

수율 96.5%

N-carbobenzoxydopamine

수율 96.5%

용매

water

반응 조건

후처리

1. 1
   기타To the solution thus obtained
2. 2
   온도to maintain the pH value of the reaction mixture to 9
3. 3
   기타stirring for 2 hours
4. 4
   추출extracted with diethyl ether
5. 5
   건조Next, it was dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off
7. 7
   세척After washing the residue with petroleum ether
8. 8
   기타the crude crystals thus obtained
9. 9
   기타were recrystallized from ethanol/n-hexane (1 : 1 by volume)

실험 절차

38.2 g (100 mmol) of sodium borate and 18.9 g (100 mmol) of dopamine hydrochloride were dissolved in 250 ml of water. To the solution thus obtained, was added a 2 N sodium hydroxide solution under a nitrogen gas stream to adjust the pH value to 9. Then 17.1 g (100 mmol) of benzyloxycarbonyl chloride was added dropwise thereto while stirring at 15° C. for 4 hours. Simultaneously, a 2 N sodium hydroxide solution was added to maintain the pH value of the reaction mixture to 9. After continuing the stirring for 2 hours, the mixture was adjusted to pH 1 to 2 with hydrochloric acid and then extracted with diethyl ether. Next, it was dried over anhydrous magnesium sulfate and the solvent was distilled off. After washing the residue with petroleum ether, the crude crystals thus obtained were recrystallized from ethanol/n-hexane (1 : 1 by volume). Thus 27.6 g (yield: 96.5% of the desired compound (m.p.: 134°- 135 ° C.) was obtained in the form of white crystals.

출처