반응 #59971

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( 4j )

2-(((4-(2-(8-ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

3-chloroperbenzoic acid

2-(2-methyl-1,3-dioxolan-2-yl)ethanol

→

title compound

수율 14.4%

2-(((3-methyl-4-(2-(2-methyl-1,3-dioxolan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

수율 14.4%

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후처리

1. 1
   기타obtained in the step (69b)

실험 절차

The same procedure as in the steps (4f) to (4j) of Example 4 (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using 2-(2-methyl-1,3-dioxolan-2-yl)ethanol obtained in the step (69b) to obtain the title compound (410 mg, total 14.4% yield) as a light yellow solid.

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