반응 #59945

반응 방정식

( 1g )

2-(((4-((5,5-dimethyl-1,3-dioxan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

4-chloro-2,3,5-trimethylpyridine 1-oxide

(2-(fluoromethyl)-1,3-dioxan-2-yl)methanol

→

title compound

수율 12.0%

2-(((4-((2-(fluoromethyl)-1,3-dioxan-2-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole sodium salt

수율 12.0%

반응 조건

실험 절차

The same procedure as in the steps (1c) to (1g) of Example 1 was repeated using 4-chloro-2,3,5-trimethylpyridine 1-oxide and (2-(fluoromethyl)-1,3-dioxan-2-yl)methanol to obtain the title compound (331 mg, 5 steps: 12%) as a yellow solid.

출처