반응 #59871

반응 방정식

(2-methoxy-1,3-dioxan-5-yl)methanol

sodium hydride

4-chloro-2,3-dimethylpyridine 1-oxide

→

title compound

수율 49.5%

4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-2,3-dimethylpyridine 1-oxide

수율 49.5%

용매

dimethylsulfoxide

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   온도After the reaction mixture was cooled to room temperature
3. 3
   농축it was concentrated
4. 4
   기타The residue was purified by silica gel column chromatography (NH silica gel, elution solvent: ethyl acetate/methanol)

실험 절차

To a dimethylsulfoxide (10 ml) solution of the (2-methoxy-1,3-dioxan-5-yl)methanol (2.0 g, 13.5 mmol) obtained in the same manner of step (6a), sodium hydride, in oil (770 mg, 14.9 mmol as the content was regarded as 55%) was added at room temperature. To the mixture, 4-chloro-2,3-dimethylpyridine 1-oxide (2.13 g, 13.5 mmol) was added and the mixture was stirred at 60° C. for 2.5 hours. After the reaction mixture was cooled to room temperature, it was concentrated. The residue was purified by silica gel column chromatography (NH silica gel, elution solvent: ethyl acetate/methanol) to obtain the title compound (1.8 g, 49.5% yield), which was a cis and trans (1:1) mixture, as a yellow oil.

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