반응 #59836

반응 방정식

trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester

isopropylmagnesiumbromide

lithium bromide

→

aimed compound

수율 33.0%

2-bromo-6-isopropylnaphthalene

수율 33.0%

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타equipped
2. 2
   온도with cooling pipe
3. 3
   기타After the reaction terminated
4. 4
   workup.ADDITIONadding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution
5. 5
   기타an organic layer was separated
6. 6
   세척washed with the use of sodium bicarbonate solution and sodium chloride solution
7. 7
   건조by drying with the use of magnesium sulfate
8. 8
   기타After removing the solvent
9. 9
   workup.DISTILLATIONby distillation
10. 10
    기타by means of a rotary evaporator

실험 절차

Under an atmospheric argon gas flow, trifluoromethane sulfonic acid-6-bromo-2-naphthyl ester in an amount of 32 g (90 mmol), dichloro(diphenylphosphinoferrocene)palladium in an amount of 3.6 g (5% by mol), lithium bromide in an amount of 7.8 g (90 mmol) and desiccated tetrahydrofuran in an amount of 100 milliliter were placed into three necked-flask equipped with cooling pipe and having a capacity of 500 milliliter, and then, the resultant solution was cooled down to −20° C. After slowly dripping isopropylmagnesiumbromide in an amount of 90 milliliter (90 mmol, 1 mol/liter (tetrahydrofuran)) into the flask, the resultant solution was stirred under heating at the temperature of 80° C. for 4 hours. After the reaction terminated, adding dilute hydrochloric acid in an amount of 100 milliliter into the reacted solution, an organic layer was separated and washed with the use of sodium bicarbonate solution and sodium chloride solution, followed by drying with the use of magnesium sulfate. After removing the solvent by distillation by means of a rotary evaporator, the resultant crude product was refined by means of column chromatography (silicagel, hexane/dichloromethane=90/10), and as a result, 9.4 g of aimed compound (white crystal) was obtained (yield: 33%).

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