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N-Cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide

Intermediate 40

N-Cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide

triethylorthopropionate

→

N-cyclopropyl-4′-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1′-biphenyl-3-carboxamide

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후처리

1. 1
   기타The excess triethylorthopropionate was evaporated under vacuum
2. 2
   기타the residue purified by bond-elut (silica)
3. 3
   세척eluting with an ethyl acetate/cyclohexane gradient
4. 4
   기타The solvent was evaporated from the product fractions under vacuum

실험 절차

N-Cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide (Intermediate 40) (50 mg) in triethylorthopropionate (5 ml) was heated at 150° C. for 18 hours. The excess triethylorthopropionate was evaporated under vacuum and the residue purified by bond-elut (silica), eluting with an ethyl acetate/cyclohexane gradient. The solvent was evaporated from the product fractions under vacuum to give N-cyclopropyl-4′-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1′-biphenyl-3-carboxamide.

출처