반응 #59677
ord-f706d26ebb73471d909c51f1695ddd4a
반응 조건
온도
61°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The solvent was removed in vacuo and excess thionyl chloride
- 2기타removed
- 3기타by azeotroping with toluene (3×30 ml)
실험 절차
Thionyl chloride (8.2 ml, 112.5 mmol) was added to a mixture of 3-iodo-4-methylbenzoic acid (18.5 g, 75 mmol) in chloroform (100 ml) and heated at 61° C. for 16 hours. The solvent was removed in vacuo and excess thionyl chloride removed by azeotroping with toluene (3×30 ml). The desired product was formed as a beige solid (19.5 g 93%) and used in subsequent reactions without further purification.