반응 #59653

반응 방정식

levofloxacin

H2O

→

levofloxacin hemihydrate

수율 84.0%

용매

DMSO

반응 조건

후처리

1. 1
   온도the mixture was cooled to RT
2. 2
   여과The precipitate was filtrated under vacuum
3. 3
   세척washed with 1 ml of a mixture DMSO:H2O 1:5
4. 4
   기타dried at 60° C. in an air-flow oven

실험 절차

1 g of levofloxacin crude was put in suspension in 1.5 ml of DMSO. The mixture was heated to 108° C. until complete dissolution of the material. Then H2O (7.5 ml) was added over 10 minutes and the mixture was cooled to RT. The precipitate was filtrated under vacuum, washed with 1 ml of a mixture DMSO:H2O 1:5 and dried at 60° C. in an air-flow oven to give 840 mg (84%) of purified levofloxacin hemihydrate.

출처