반응 #59650

반응 방정식

levofloxacin

ascorbic acid

→

levofloxacin hemihydrate

용매

n-BuOH

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux temperature
3. 3
   여과a hot filtration
4. 4
   기타The solution was then evaporated to dryness and n-BuOH (10 ml)
5. 5
   workup.ADDITIONwas added
6. 6
   온도The mixture was heated
7. 7
   온도to reflux until complete dissolution
8. 8
   여과The precipitate was filtrated under vacuum
9. 9
   세척washed with n-BuOH (4 ml)
10. 10
    기타dried at 60° C. in a vacuum oven

실험 절차

1.5 g of levofloxacin crude and 36 mg of ascorbic acid were put in suspension in 9.5 ml of n-BuOH under inert atmosphere. The mixture was heated to reflux temperature and a hot filtration was performed. The solution was then evaporated to dryness and n-BuOH (10 ml) was added. The mixture was heated to reflux until complete dissolution and then cooled to RT over a period of 1.5 hour. The precipitate was filtrated under vacuum, washed with n-BuOH (4 ml) and dried at 60° C. in a vacuum oven to give 840 mg (56%) of purified levofloxacin hemihydrate.

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