반응 #59649

반응 방정식

levofloxacin

→

levofloxacin hemihydrate

수율 118.5%

용매

n-BuOH

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux temperature
3. 3
   workup.DISSOLUTIONuntil complete dissolution of the material
4. 4
   여과The precipitate was filtrated under vacuum
5. 5
   세척washed with n-BuOH
6. 6
   기타dried at 60° C. in a vacuum oven

실험 절차

1 g of levofloxacin crude was put in suspension in 7 ml of n-BuOH. The mixture was heated to reflux temperature until complete dissolution of the material. Then the solution was cooled to RT over a period of 2.5 hours. The precipitate was filtrated under vacuum, washed with n-BuOH and dried at 60° C. in a vacuum oven to give 810 mg (81%) of purified levofloxacin hemihydrate.

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