반응 #596007

반응 방정식

4-chloro-2-fluoro-1-iodobenzene

ethynyl(trimethyl)silane

→

desired product

수율 56.5%

((4-chloro-2-fluorophenyl)ethynyl)trimethylsilane

수율 56.5%

용매

DMSO

반응 조건

후처리

1. 1
   기타The reaction mass quenched in water
2. 2
   추출extracted with ethyl acetate
3. 3
   농축concentrated

실험 절차

To a solution of 4-chloro-2-fluoro-1-iodobenzene (2.0 g, 7.8 mmol) in DMSO (10 mL) was added ethynyl(trimethyl)silane (1.14 g, 11.0 mmol), copper iodide (0.029 g, 0.15 mmol), bis(triphenylphosphine) palladium(II) chloride (0.218 g, 0.3 mmol) and TEA (1 mL). The reaction mass was stirred at RT for 4-5 h. The reaction mass quenched in water, passed through celite bed and extracted with ethyl acetate and concentrated to afford 1.0 g of desired product.

출처