반응 #5954

반응 방정식

3,4,5-trimethoxyphenylisothiocyanate

3-[4-(2-chlorophenyl) -1-piperazinyl]propanol

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title compound

수율 42.6%

4-(2-Chlorophenyl)-1-(3-[3,4,5-trimethoxyphenyl(thiocarbamoyl)oxy]propyl)piperazine, hydrochloride

수율 42.6%

용매

toluene

반응 조건

후처리

1. 1
   온도was refluxed for 16 h
2. 2
   기타The solvent was evaporated
3. 3
   여과filtered
4. 4
   기타evaporated to dryness
5. 5
   workup.ADDITIONwhich was treated with hydrogen chloride in ether

실험 절차

A mixture of 3,4,5-trimethoxyphenylisothiocyanate (2.0 mmol) (produced as in Example 22) and 3-[4-(2-chlorophenyl) -1-piperazinyl]propanol (510 mg; 2.0 mmol) in toluene (40 ml) was refluxed for 16 h. The solvent was evaporated and the residue resuspended in ethyl acetate filtered and evaporated to dryness. The residue was submitted to flash chromatography on silica gel 60 eluting with toluene/ethyl acetate (1:1). The product was taken up in ethanol, which was treated with hydrogen chloride in ether to give 220 mg of the title compound. M.p. 182°-183° C. MS (70 eV): m/z 479 (M+, 0.5%), 254 (47), 225 (82), 209 (100), 182 (29).

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