반응 #595377

반응 방정식

2-chlorobenzenesulfonyl chloride

3-bromo-1H-pyrazolo[4,3-c]pyridine

sodium hydride

→

3-bromo-1-(2-chlorophenylsulfonyl)-1H-pyrazolo[4,3-c]pyridine

용매

THF

반응 조건

후처리

1. 1
   workup.ADDITIONAfter addition
2. 2
   기타The reaction mixture was quenched by the addition of water
3. 3
   추출The product was extracted into ethyl acetate
4. 4
   세척the organic layer was washed with brine
5. 5
   기타The organic solvent was evaporated under reduced pressure

실험 절차

To a solution of 3-bromo-1H-pyrazolo[4,3-c]pyridine (198 mg, 1,0 mmol) in 10 ml THF was added portion wise at 0° C. sodium hydride (101 mg, 4 mmol, 95%). After addition was complete, 2-chlorobenzenesulfonyl chloride (495 mg, 2.347 mmol) was added and the reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched by the addition of water. The product was extracted into ethyl acetate and the organic layer was washed with brine. The organic solvent was evaporated under reduced pressure to give 3-bromo-1-(2-chlorophenylsulfonyl)-1H-pyrazolo[4,3-c]pyridine as a yellow oil. The product was used in the next step without further purification.

출처