반응 #595376

반응 방정식

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

수율 97.4%

용매

CH2Cl2

반응 조건

후처리

1. 1
   농축After completion the reaction mixture was concentrated under reduced pressure
2. 2
   기타the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

실험 절차

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

출처