반응 #595371

반응 방정식

H2SO4

CO2

n-BuLi

diisopropylamine

1,4-difluoro-2-methoxybenzene

LDA

→

title compound

3,6-difluoro-2-methoxybenzoic acid

용매

diethyl ether

THF

THF

반응 조건

후처리

1. 1
   기타the resulting precipitate was collected
2. 2
   세척washed with H2O
3. 3
   기타dried

실험 절차

A solution of 1,4-difluoro-2-methoxybenzene (i-6a) (2.88 g, 20 mmol) in THF (5 mL) was added to a solution of LDA freshly prepared from n-BuLi (10M solution in hexane, 2.2 mL, 22 mmol) and diisopropylamine (2.28 g, 22.8 mmol) in THF (20 mL) at −60° C. After 30 min, a freshly prepared solution of CO2 in diethyl ether (20 mL) was quickly added. Then aq. H2SO4 was added, and the resulting precipitate was collected and washed with H2O, and dried to give the title compound (i-6b) as white crystals. LCMS (ESI) calc'd for C8H6F2O3 [M+H]+: 189. found: 189.

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