반응 #595361

반응 방정식

compound

2-Chloro-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}thio)-4-(4-{[(2S)-2,3-dihydroxypropyl]-oxy}phenyl)pyridine-3,5-dicarbonitrile

methyl N-methylglycinate hydrochloride

triethylamine

→

Methyl N-[6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}thio)-3,5-dicyano-4-(4-{[(2S)-2,3-dihydroxypropyl]oxy}-phenyl)pyridin-2-yl]-N-methylglycinate

용매

DMF

반응 조건

후처리

1. 1
   기타The solvent is then removed on a rotary evaporator
2. 2
   기타the residue is purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)
3. 3
   기타After removal of the solvent
4. 4
   기타on a rotary evaporator
5. 5
   기타the product is obtained as a white solid

실험 절차

108 mg (0.20 mmol) of the compound from Example 103A are dissolved in 3 ml of dry DMF, and 54 mg (0.39 mmol) of methyl N-methylglycinate hydrochloride and 59 mg (0.59 mmol) of triethylamine are added. The reaction mixture is stirred at RT for 8 h. The solvent is then removed on a rotary evaporator and the residue is purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5). After removal of the solvent on a rotary evaporator, the product is obtained as a white solid.

출처