반응 #595352

반응 방정식

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

용매

methanol

water

반응 조건

후처리

1. 1
   추출extracted three times with in each case 10 ml of diethyl ether
2. 2
   건조The combined organic phases are dried over magnesium sulfate
3. 3
   기타the solvent is removed on a rotary evaporator
4. 4
   기타The product obtained
5. 5
   기타is used without further purification in the subsequent reaction

실험 절차

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

출처