반응 #595347

반응 방정식

compound

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

반응 조건

후처리

1. 1
   기타excess thionyl chloride is then removed under reduced pressure
2. 2
   세척washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   건조The organic phase is dried over magnesium sulfate
4. 4
   기타the solvent is removed on a rotary evaporator
5. 5
   기타The product obtained
6. 6
   기타is used without further purification in the subsequent reactions

실험 절차

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

출처