반응 #595346

반응 방정식

lithium aluminum hydride

compound

Methyl 5-(4-chlorophenyl)-1,3-oxazole-4-carboxylate

water

sodium hydroxide

→

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

용매

THF

THF

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   온도the reaction solution is slowly warmed to RT
3. 3
   workup.STIRRINGWith stirring
4. 4
   온도the mixture is then heated
5. 5
   온도at reflux for 2 h
6. 6
   온도The mixture is then cooled again to 0° C.
7. 7
   workup.STIRRINGthe mixture is stirred at RT for 3 h
8. 8
   기타The precipitate formed
9. 9
   여과is filtered off
10. 10
    기타the filtrate is freed from the solvent on a rotary evaporator
11. 11
    기타The residue is used without further purification in the subsequent reaction

실험 절차

166 mg (4.38 mmol) of lithium aluminum hydride are initially charged in 10 ml of dry THF and cooled to 0° C. A solution of 260 mg (1.09 mmol) of the compound from Example 37A in 10 ml of dry THF is added dropwise. After the addition has ended, the reaction solution is slowly warmed to RT and stirred at this temperature for 1 h. With stirring, the mixture is then heated at reflux for 2 h. The mixture is then cooled again to 0° C., 0.4 ml of water and 0.8 ml of 1 N aqueous sodium hydroxide solution are added carefully and the mixture is stirred at RT for 3 h. The precipitate formed is filtered off, and the filtrate is freed from the solvent on a rotary evaporator. The residue is used without further purification in the subsequent reaction.

출처