반응 #595321

반응 방정식

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

수율 71.0%

Butyl cyclopropanesulfonate

수율 71.0%

반응 조건

후처리

1. 1
   온도The mixture was slowly warmed at room temperature
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   세척The organic phase was washed with water, brine
5. 5
   건조dried (MgSO4)
6. 6
   농축concentrated

실험 절차

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

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