반응 #59401

반응 방정식

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Lithium hydroxide monohydrate

hydrochloric acid

→

title compound

수율 95.6%

(R)-1-carboxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

수율 95.6%

용매

tetrahydrofuran

methanol

water

반응 조건

후처리

1. 1
   추출was followed by extraction with ethyl acetate (20 mL twice)
2. 2
   세척The combined organic layers were washed with brine (10 mL)
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   기타evaporated under vacuum

실험 절차

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 7) (13 mg) was dissolved in a 2:2:1 mixture of tetrahydrofuran, methanol, and water (5 mL). Lithium hydroxide monohydrate (3 mg) was added, and the resulting mixture was stirred at room temperature for 2 h. Addition of 1.0 M aqueous hydrochloric acid (10 mL) was followed by extraction with ethyl acetate (20 mL twice). The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, and evaporated under vacuum to provide the title compound (12 mg). HPLC/MS [M+H]+, 398.

출처