반응 #59391

반응 방정식

water

compound

4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidine Hydrochloride

potassium carbonate

ethyl bromoacetate

→

title compound

2-(4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidin-1-yl)acetic Acid Ethyl Ester

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   추출was extracted by tert-butyl methyl ether (160 ml)
2. 2
   세척The organic layer was washed by water (80 ml×2)
3. 3
   농축concentrated

실험 절차

To a solution of the compound prepared in example 1 (19.8 g) in N,N-dimethylformamide (53 ml) were added potassium carbonate (18.4 g) and ethyl bromoacetate (5.89 ml) and the mixture was stirred for 1.5 hours at 50° C. To the reaction mixture was added water (160 ml) and it was extracted by tert-butyl methyl ether (160 ml). The organic layer was washed by water (80 ml×2) and concentrated to give the title compound (23.4 g) having the following physical data.

출처