반응 #593271

반응 방정식

6-Amino-2-(4-ethoxyphenyl)-1-ethyl-1H-indole-3-carbonitrile

ethyl chloroformate

→

[3-cyano-2-(4-ethoxyphenyl)-1-ethyl-1H-indol-6-yl]-carbamic acid ethyl ester

용매

pyridine

반응 조건

후처리

1. 1
   기타to furnish
2. 2
   기타after purification

실험 절차

6-Amino-2-(4-ethoxyphenyl)-1-ethyl-1H-indole-3-carbonitrile (31 mg, 0.1 mmol), compound 833, prepared in example 1BR, step B is treated with ethyl chloroformate (16 mg, 0.15 mmol) in pyridine (1.0 mL) at room temperature overnight to furnish, after purification using column chromatography [3-cyano-2-(4-ethoxyphenyl)-1-ethyl-1H-indol-6-yl]-carbamic acid ethyl ester (30 mg, 79%).

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