반응 #59315

반응 방정식

(2,2,2-trifluoro-ethyl)-carbamic acid (S)-1-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester

ethyl acetate

→

title compound

수율 70.0%

(2,2,2-Trifluoro-ethyl)-carbamic acid (S)-1-[(S)-5-(2-hydroxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester

수율 70.0%

용매

heptane

반응 조건

후처리

1. 1
   기타the title compound was prepared in the same manner as example 3

실험 절차

Using (2,2,2-trifluoro-ethyl)-carbamic acid (S)-1-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester, the title compound was prepared in the same manner as example 3. Final chromatography (silica, gradient of ethyl acetate in heptane 5-90%) afforded the title compound as white solid (70%). MS: m/e=466(M+H+).

출처