반응 #59243

ord-f9c19a0ec1e048cab0e3cb38330568f2

반응 방정식

C#Cc1cn(C2OC(CO)C(O)C2(C)O)c2ncnc(NO)c12
title compound
C#Cc1cn(C2OC(CO)C(O)C2(C)O)c2ncnc(NO)c12
2-(5-Ethynyl-4-hydroxyamino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
[H][H]
hydrogen
→
C=Cc1cn(C2OC(CO)C(O)C2(C)O)c2ncnc(NO)c12
2-(4-Hydroxyamino-5-vinyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

반응물

C#Cc1cn(C2OC(CO)C(O)C2(C)O)c2ncnc(NO)c12
title compound
C#Cc1cn(C2OC(CO)C(O)C2(C)O)c2ncnc(NO)c12
2-(5-Ethynyl-4-hydroxyamino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
[H][H]
hydrogen

시약

CC(=O)[O-].CC(=O)[O-].[Pb+2].[Pd]
Lindlar's catalyst

용매

C1CCOC1
THF

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타is consumed

실험 절차

The title compound from Example 29 is dissolved in THF and placed under hydrogen (1 atm) in the presence of Lindlar's catalyst until one mole of hydrogen is consumed.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07425547B2uspto-grants-2008_09