반응 #5923

반응 방정식

4-bromobutyryl chloride

2-(4-chlorophenyl)-3,4-dihydro2H-1,4-benzothiazine

sodium hydrogen carbonate

→

4-(4-bromobutyryl)-2-(4-chlorophenyl)-3,4-dihyro-2H-1,4-benzothiazine

수율 93.2%

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   세척The ethyl acetate layer is washed
2. 2
   기타dried
3. 3
   workup.DISTILLATIONdistilled
4. 4
   기타to remove the solvent
5. 5
   기타The residue is recrystallized from ethyl acetate-n-hexane

실험 절차

To a mixture of 2-(4-chlorophenyl)-3,4-dihydro2H-1,4-benzothiazine (1.08 g), ethyl acetate (20 ml) and aqueous sodium hydrogen carbonate solution (20 ml) is added dropwise a solution of 4-bromobutyryl chloride (0.97 g) in ethyl acetate (5 ml) with stirring under ice cooling. The ethyl acetate layer is washed, dried and distilled to remove the solvent. The residue is recrystallized from ethyl acetate-n-hexane to give 4-(4-bromobutyryl)-2-(4-chlorophenyl)-3,4-dihyro-2H-1,4-benzothiazine (1.58 g, yield 93%).

출처