반응 #592255

반응 방정식

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

수율 27.0%

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

수율 27.0%

용매

DCE

반응 조건

후처리

1. 1
   농축the mixture was concentrated in vacuo
2. 2
   기타purified by prep

실험 절차

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.

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