반응 #592

ord-b66bb670a88e49d4a4b3a67904494b50

반응 방정식

CN1CC(c2ccccc2)Oc2nc(Cl)ccc2C1=O
CN1CC(c2ccccc2)Oc2nc
Cc1nccn1-c1ccc(N)cc1
Cc1nccn1-c1ccc(N)cc1
→
Cc1nccn1-c1ccc(Nc2ccc3c(n2)OC(c2ccccc2)CN(C)C3=O)cc1
Cc1nccn1-c1ccc(Nc2cc
수율 74.9%

반응물

CN1CC(c2ccccc2)Oc2nc(Cl)ccc2C1=O
CN1CC(c2ccccc2)Oc2nc(Cl)ccc2C1
Cc1nccn1-c1ccc(N)cc1
Cc1nccn1-c1ccc(N)cc1

시약

O=C([O-])[O-].[Cs+].[Cs+]
O=C([O-])[O-].[Cs+].[Cs+]
c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1
c1ccc(-c2ccccc2P(C2CCCCC2)C2CC
CC(=O)O.CC(=O)O.[Pd]
CC(=O)O.CC(=O)O.[Pd]

용매

COCCOC
COCCOC

반응 조건

온도
100°CELSIUS

실험 절차

Not continued.

출처

750 AstraZeneca ELN dataset