반응 #59127

반응 방정식

[4-(methoxycarbonyl)tetrahydro-2H-pyran-4-yl]acetic acid

Thionyl chloride

→

methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate

수율 99.0%

반응 조건

후처리

1. 1
   기타The solvent was then removed
2. 2
   기타mixture was azeotroped with dichloroethane three times

실험 절차

Thionyl chloride (20 mL) was added to [4-(methoxycarbonyl)tetrahydro-2H-pyran-4-yl]acetic acid (970 mg, 4.80 mmol) and the solution was stirred at rt for 3 h. The solvent was then removed and mixture was azeotroped with dichloroethane three times to afford methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate (1.05 g, 99%), which was used without purification in the next step.

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