반응 #59097

반응 방정식

Sodium nitrite

4-tert-butyl aniline

hydrogen fluoride-pyridine

→

1-tert-butyl-4-fluorobenzene

반응 조건

후처리

1. 1
   기타the bomb was sealed
2. 2
   온도heated at 85° C. for 1 h
3. 3
   기타Solution was then quenched with water/ice
4. 4
   추출extracted with ethyl ether
5. 5
   세척Organics washed with brine
6. 6
   건조dried with sodium sulfate
7. 7
   농축concentrated

실험 절차

In a steel bomb were combined 4-tert-butyl aniline (1 eq) and 70% hydrogen fluoride-pyridine (25 g/gm aniline). Sodium nitrite (1.5 eq) was then added portion wise over 5 minutes. The resulting solution was allowed to stir for 1 h at room temperature and then the bomb was sealed and heated at 85° C. for 1 h. Solution was then quenched with water/ice and extracted with ethyl ether. Organics washed with brine and dried with sodium sulfate and concentrated to afford 1-tert-butyl-4-fluorobenzene.

출처