반응 #59079

반응 방정식

4-chloro-3-(3-fluoropyridin-4-yl)benzenamine

sodium bicarbonate

thiophosgene

→

4-(2-chloro-5-isothiocyanatophenyl)-3-fluoropyridine

용매

acetone

반응 조건

후처리

1. 1
   기타Reaction
2. 2
   농축then concentrated
3. 3
   기타partitioned between ethyl acetate and water
4. 4
   건조Organic layer dried over sodium sulfate and sodium bicarbonate
5. 5
   농축concentrated

실험 절차

The mixture containing 4-chloro-3-(3-fluoropyridin-4-yl)benzenamine (1 eq) and sodium bicarbonate (2 eq) in acetone was treated with thiophosgene (2 eq) and stirred for 5 minutes at 0° C. Reaction then concentrated and partitioned between ethyl acetate and water. Organic layer dried over sodium sulfate and sodium bicarbonate and concentrated to give 4-(2-chloro-5-isothiocyanatophenyl)-3-fluoropyridine. HPLC=5.54 min; MS: MH+=265.

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