반응 #590662

반응 방정식

PCC

3-benzyloxy-1-propanol

→

3-(benzyloxy)propanal

수율 79.0%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   여과filtrated through Celite
2. 2
   농축concentrated
3. 3
   기타The residue was purified by column chromatography on silica gel (1-10% ethyl acetate/hexanes)

실험 절차

To a suspension of PCC (606 mg, 2.82 mmol) in anhydrous dichloromethane (8 mL) at room temperature under N2 was added a solution of 3-benzyloxy-1-propanol (310 mg, 1.88 mmol) in anhydrous dichloromethane. The reaction mixture was stirred overnight at room temperature, filtrated through Celite, and concentrated. The residue was purified by column chromatography on silica gel (1-10% ethyl acetate/hexanes) to give 3-(benzyloxy)propanal (243 mg, 79%).

출처