반응 #59063

반응 방정식

sodium hydroxide

ethylpiperidine-4-carboxylate

2-bromo-1-methoxyethane

potassium carbonate

→

1-(2-methoxyethyl)piperidine-4-carboxylic acid

용매

ethanol

water

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 16 h
2. 2
   여과The mixture was then filtered
3. 3
   농축concentrated
4. 4
   기타The resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene

실험 절차

To ethylpiperidine-4-carboxylate (1 eq) in ethanol was added 2-bromo-1-methoxyethane (1 eq) and potassium carbonate 2 eq) and the resulting mixture was refluxed for 16 h. The mixture was then filtered and concentrated. To it was then added ethanol and water (3:1) and sodium hydroxide (1 eq) and it was refluxed for 16 h. The resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene. MS: MH+=188.

출처