반응 #59056

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p-Toluenesulfonic acid monohydrate

4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid

compound 1

4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid

→

title compound

수율 45.0%

4′-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl-amino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid p-toluenesulfonate

수율 45.0%

용매

1,4-dioxane

diethyl ether

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후처리

1. 1
   여과the precipitate was collected by filtration

실험 절차

p-Toluenesulfonic acid monohydrate (0.042 g) was added to a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid (compound 1, 0.094 g) in 1,4-dioxane (1.1 mL), and the mixture was stirred at room temperature for 1 hr. The clear solution was diluted with an excess amount of diethyl ether, and the precipitate was collected by filtration to afford the title compound (0.059 g) as a white amorphous. The structure and physical data were shown in table 4.

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