반응 #5905

반응 방정식

2-chloropropionyl chloride

aluminium trichloride

fluorobenzene

→

2-chloro-1-(4-fluorophenyl)-1-propanone

용매

dichloromethane

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.STIRRINGThe resulting mixture was stirred for one hour
2. 2
   workup.WAITto stand for 16 hours
3. 3
   workup.ADDITIONpoured on to an icehydrochloric acid mixture
4. 4
   workup.STIRRINGThe two phase mixture was vigorously stirred at room temperature for 11/2 hours
5. 5
   기타separated
6. 6
   세척the aqueous layer washed with dichloromethane (2×50 ml)
7. 7
   세척The combined organic extracts were then washed with aqueous sodium hydroxide (3N, 2×100 ml), water (1×100 ml) and brine (1×100 ml)
8. 8
   건조dried (MgSO4)
9. 9
   기타evaporated under reduced pressure

실험 절차

A solution of 2-chloropropionyl chloride (49 ml) in dichloromethane (50 ml) was added to a mixture of anhydrous aluminium trichloride (55.5 g) in dichloromethane (120 ml). The mixture was stirred for 10 minutes at room temperature and then a solution of fluorobenzene (39.5 ml) in dichloromethane (30 ml) was added dropwise. The resulting mixture was stirred for one hour, allowed to stand for 16 hours and then poured on to an icehydrochloric acid mixture. The two phase mixture was vigorously stirred at room temperature for 11/2 hours, separated and the aqueous layer washed with dichloromethane (2×50 ml). The combined organic extracts were then washed with aqueous sodium hydroxide (3N, 2×100 ml), water (1×100 ml) and brine (1×100 ml), dried (MgSO4) and evaporated under reduced pressure to afford 2-chloro-1-(4-fluorophenyl)-1-propanone, 71.3 g.

출처