반응 #59045

반응 방정식

Water

Methanesulfonyl chloride

ethyl [4′-(2-hydroxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate

triethylamine

→

ethyl [4′-(2-methanesulfonyloxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate

용매

ethyl acetate

methylene chloride

반응 조건

후처리

1. 1
   온도cooled
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hr
3. 3
   기타The organic layer was separated
4. 4
   세척washed with water and brine
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타The solvent was evaporated under reduced pressure

실험 절차

Methanesulfonyl chloride (0.17 mL) was added to an ice-cooled mixture of ethyl [4′-(2-hydroxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate (0.58 g) and triethylamine (0.36 mL) in methylene chloride (5 mL) with stirring, and the mixture was stirred at room temperature for 1 hr. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford ethyl [4′-(2-methanesulfonyloxyethoxy)-2′,6′-dimethylbiphenyl-4-yloxy]acetate.

출처