반응 #590410

반응 방정식

1-(3,4-bis-benzyloxy-phenyl)-cyclopropanecarbonitrile

→

1-(3,4-dihydroxy-phenyl)-cyclopropanecarbonitrile

수율 92.0%

용매

MeOH

반응 조건

후처리

1. 1
   여과The catalyst was filtered off through a celite pad
2. 2
   기타the filtrate was evaporated under vacuum

실험 절차

To a solution of 1-(3,4-bis-benzyloxy-phenyl)-cyclopropanecarbonitrile (10 g, 28 mmol) in MeOH (50 mL) was added Pd/C (0.5 g) under nitrogen atmosphere. The mixture was stirred under hydrogen atmosphere (1 atm) at room temperature for 4 h. The catalyst was filtered off through a celite pad and the filtrate was evaporated under vacuum to give 1-(3,4-dihydroxy-phenyl)-cyclopropanecarbonitrile (4.5 g, 92%). 1H NMR (DMSO 400 MHz) δ 9.06 (br s, 2H), 6.67-6.71 (m, 2H), 6.54 (dd, J=2.4, 8.4 Hz, 1H), 1.60-1.57 (m, 2H), 1.30-1.27 (m, 2H).

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