반응 #58932

반응 방정식

4-nitrophenol

4-chloromethyl-1,3-thiazole hydrochloride

potassium carbonate

N,N-dimethylformamide

→

4-[(4-nitrophenoxy)methyl]-1,3-thiazole

수율 61.0%

용매

Water

반응 조건

후처리

1. 1
   추출the mixture was extracted with ethyl acetate-tetrahydrofuran
2. 2
   세척The organic layer was washed with saturated brine
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated

실험 절차

A mixture of 4-nitrophenol (3.92 g), 4-chloromethyl-1,3-thiazole hydrochloride (4.0 g), potassium carbonate (8.13 g) and N,N-dimethylformamide (100 mL) was stirred at room temperature for 40 hrs. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate-tetrahydrofuran. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to give 4-[(4-nitrophenoxy)methyl]-1,3-thiazole as colorless crystals (3.38 g, yield 61%). Recrystallization thereof from ethyl acetate-hexane gave colorless prism crystals. melting point: 175-176° C.

출처