반응 #58926

반응 방정식

4-chloromethyl-2-ethyl-1,3-oxazole

triphenylphosphine

→

[(2-ethyl-1,3-oxazol-4-yl)methyl]triphenylphosphonium chloride

수율 81.7%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 15 hrs
3. 3
   농축The reaction mixture was concentrated
4. 4
   세척the obtained crystals were washed with diethyl ether

실험 절차

A mixture of 4-chloromethyl-2-ethyl-1,3-oxazole (4.87 g), triphenylphosphine (7.89 g) and acetonitrile (100 mL) was heated under reflux for 15 hrs. The reaction mixture was concentrated, and the obtained crystals were washed with diethyl ether to give [(2-ethyl-1,3-oxazol-4-yl)methyl]triphenylphosphonium chloride as colorless crystals (10.02 g, yield 79%). Recrystallization thereof from acetonitrile-diethyl ether gave colorless prism crystals. melting point: 222-223° C.

출처