반응 #58896

반응 방정식

2,4-dihydroxybenzaldehyde

trifluoromethanesulfonic anhydride

sodium hydride

ortho-tolylboronic acid

sodium carbonate

pyridine

2-dimethylamino ethylchloride

→

3-(2-Dimethylamino-ethoxy)-2′-methyl-biphenyl-4-carbaldehyde

용매

water

DME

methylene chloride

toluene

반응 조건

후처리

1. 1
   기타the temperature below 5° C
2. 2
   세척After 10 min the mixture was washed with water
3. 3
   농축the organic phase was concentrated under reduced pressure
4. 4
   온도The mixture was refluxed for 17 h under Argon
5. 5
   추출extracted with ethyl acetate
6. 6
   workup.DISSOLUTIONThe crude black oil (4.6 g) was dissolved in DMF (75 ml)
7. 7
   온도the mixture was heated at 80° C. for 3 days
8. 8
   세척The mixture was washed with saturated sodium bicarbonate
9. 9
   농축concentrated under reduced pressure
10. 10
    기타purified by chromatography
11. 11
    세척The resulting yellow oil was washed with hot heptane giving the product as relative pure oil (GC-MS)

실험 절차

A solution of 2,4-dihydroxybenzaldehyde (27 mmol) in methylene chloride (10 ml) and pyridine (30 mmol) was slowly added trifluoromethanesulfonic anhydride (32 mmol) keeping the temperature below 5° C. After 10 min the mixture was washed with water and the organic phase was concentrated under reduced pressure. The crude brown oil (5 g), ortho-tolylboronic acid (20.4 mmol), sodium carbonate (55.5 mmol) and dichlorobis(triphenylphosphine)-palladium (II) (3 mol %) was dissolved in DME (50 ml) and water (20 ml). The mixture was refluxed for 17 h under Argon, cooled to room temperature and extracted with ethyl acetate. The crude black oil (4.6 g) was dissolved in DMF (75 ml) and sodium hydride (60% in oil, 22.5 mmol) was slowly added. A solution of 2-dimethylamino ethylchloride (22.5 mmol) in toluene (120 ml) was added and the mixture was heated at 80° C. for 3 days. The mixture was washed with saturated sodium bicarbonate, concentrated under reduced pressure and purified by chromatography. The resulting yellow oil was washed with hot heptane giving the product as relative pure oil (GC-MS). 1H-NMR (DMSO-d6) δ 10.41 (s, 1H), 7.74 (d, 2H), 7.66-7.55 (m, 1H), 7.36-6.79 (m, 4H), 4.27 (t, 2H), 2.70 (t, 2H), 2.27 (s, 3H), 2.23 (s, 6H).

출처