반응 #5889

반응 방정식

2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole

piperazine

→

2-tert-butyl-5-(4-methyl-piperidin-1-yl)-6-[(piperazin-1-yl)thiocarbonylamino]benzothiazole

수율 69.6%

용매

chloroform

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   건조dried over anhydrous sodium sulphate
3. 3
   기타evaporated
4. 4
   기타to get a sticky residue which
5. 5
   기타is triturated with isopropanol
6. 6
   여과filtered

실험 절차

A solution of 3.45 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole, described in Example 1, and 8.6 g of anhydrous piperazine in 30 ml of chloroform is stirred for 3 hours, washed with water, dried over anhydrous sodium sulphate and evaporated to get a sticky residue which is triturated with isopropanol and filtered to obtain 3 g of 2-tert-butyl-5-(4-methyl-piperidin-1-yl)-6-[(piperazin-1-yl)thiocarbonylamino]benzothiazole, melting at 278°-281°.

출처