반응 #5881

반응 방정식

water

2-tert-butyl-5-chloro-6-nitrobenzothiazole

4-methylpiperidine

potassium carbonate

→

2-tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole

용매

chloroform

dimethylsulphoxide

반응 조건

후처리

1. 1
   온도cooled
2. 2
   기타The solid obtained
3. 3
   여과filtered through a silical gel column
4. 4
   기타The filtate is evaporated

실험 절차

A solution of 32,4 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole, (described in European patent application 85810418.5 published under No. 0175650) in 300 ml of dimethylsulphoxide, is stirred and heated at 140° for 6 hours with 12.8 g of 4-methylpiperidine and 35.8 g of anhydrous potassium carbonate, cooled and poured into water. The solid obtained is dissolved in chloroform and filtered through a silical gel column. The filtate is evaporated to give 2-tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole melting at 116°-120°.

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