반응 #5880

반응 방정식

2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole

N-methylpiperazine

→

2-tert-butyl-6-[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methylpiperidin-1-yl)benzothiazole

수율 95.1%

용매

methylene chloride

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   건조dried over anhydrous sodium sulphate
3. 3
   기타evaporated

실험 절차

To a stirred solution of 90 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole in 900 ml of methylene chloride is added dropwise 26 g of N-methylpiperazine. The solution is stirred for 1 hour, washed with water, dried over anhydrous sodium sulphate and evaporated to give 110 g of 2-tert-butyl-6-[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 192°-195° C.

출처