반응 #58774

ord-bbd7d798654d40d2a16d1a5d7de0ddf3

반응 방정식

CN(C)C(N(C)C)N(C)C
tris(dimethylamino)methane
CCOC(=O)C1=C(C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
compound ( 23 )
CCOC(=O)C1=C(C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
(S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
CCC(=O)C(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)(C)c1ccccc1
example 17
CCC(=O)C(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)(C)c1ccccc1
2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
→
CCOC(=O)C1=C(/C=C/N(C)C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
crude product
CCOC(=O)C1=C(/C=C/N(C)C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
(S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

반응물

CN(C)C(N(C)C)N(C)C
tris(dimethylamino)methane
—
Example 6 1.22
CCOC(=O)C1=C(C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
compound ( 23 )
CCOC(=O)C1=C(C)[C@@](CC)(C(=O)N(CC)CC)OC1=O
(S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
CCC(=O)C(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)(C)c1ccccc1
example 17
CCC(=O)C(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)(C)c1ccccc1
2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

시약

없음

용매

CN(C)C=O
dimethyl formamide

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07423152B2uspto-grants-2008_09