반응 #58764

반응 방정식

1-[3-(5-Chloromethyl-isoxazol-3-yloxy)-propyl]-piperidine

piperidine

→

final product

수율 48.0%

4-[3-(3-Piperidin-1-yl-propoxy)-isoxazol-5-ylmethyl]-piperidine

수율 48.0%

용매

DCM

반응 조건

후처리

1. 1
   농축was concentrated
2. 2
   기타to yield the crude product (0.140 g)
3. 3
   기타The crude product was purified (SiO2: 0-5% 2 M NH3 in MeOH/DCM)

실험 절차

1-[3-(5-Chloromethyl-isoxazol-3-yloxy)-propyl]-piperidine (0.15 g, 0.80 mmol) was dissolved in DCM (5 mL) and piperidine (0.24 mL, 2.4 mmol) was added slowly. The reaction mixture was stirred overnight at rt and then was concentrated to yield the crude product (0.140 g). The crude product was purified (SiO2: 0-5% 2 M NH3 in MeOH/DCM) to give the final product (0.118 g, 47.6%). MS (ESI): exact mass calcd. for C17H29N3O2, 307.23; m/z found 308.4 [M+H]+. 1H NMR (500 MHz, CDCl3): 5.75 (s, 1H), 4.25-4.20 (m, 2H), 3.53 (s, 2H), 2.47-2.31 (m, 10H), 1.98-1.90 (m, 2H), 1.61-1.52 (m, 8H), 1.45-1.35 (m, 4H).

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