반응 #5876

반응 방정식

methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)glycine

acetic acid anhydride

formic acid

→

methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)-N-formylglycine

수율 78.7%

반응 조건

후처리

1. 1
   기타The reaction mixture is evaporated in vacuo
2. 2
   세척The organic layer is washed with a sodium hydrogen carbonate solution and water
3. 3
   기타dried
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   기타The residue is crystallized from a mixture of 2,2'-oxybispropane and hexane
7. 7
   여과The product is filtered off
8. 8
   기타dried

실험 절차

A solution of 17 parts of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)glycine in 60 parts of formic acid and 20 parts of acetic acid anhydride is stirred overnight at room temperature. The reaction mixture is evaporated in vacuo and the residue is taken up in 1,1'-oxybisethane. The organic layer is washed with a sodium hydrogen carbonate solution and water dried, filtered and evaporated. The residue is crystallized from a mixture of 2,2'-oxybispropane and hexane. The product is filtered off and dried, yielding 15 parts (78.7%) of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)-N-formylglycine.

출처